Activity Report | YANAGITA Laboratory

Lectures　講演

2025/20/25 第66回日本組織細胞化学会総会教育講演１

現場に活きる病理の知と技

～知識なき技術に制度はなく、技術なき知識に実用性は宿らない～

2025/09/15 第23回日本デジタルパソロジー・AI研究会　定時総会

特別企画：「フラジャイル」提携イベントパネリスト

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conference presentations　学会発表

Annual Histology Convention 2025.

Sep 26-30, 2025 Long Beach, California

〇Express talk E-11

Standardizing immunohistochemistry assessment:
calibration of color and intensity variation in whole slide imaging.

〇Workshop WS-40

Integration of 3D and Digital Stains with AI-Based Diagnostic Approach in pathology.

→ List of Past presentations

Writing　執筆

超実践! 病理で迫るがんゲノム医療～検査から治療まで～

臨床検査　第69巻　第10号　増刊号　2025年10月15日発行医学書院

→ List of Past Writing

Research Paper　論文

Yanagita E, Yamada H, Kobayashi T, Aimono E, Nakamura K, Hirasawa A, Nishihara H.

The DNA integrity number and concentration are useful parameters for successful comprehensive genomic profiling test for cancer using formalin-fixed paraffin embedded tissue.

Pathology International, 2023 May;73(5):198-206.

→ List of Past Papers

Other Communication Activities　発信

HER2「超低発現」にも新しい治療薬が登場　― “陰性”とされてきた乳がんにも光が差す ―　Yahoo! ニュース (2025/12/09)

HER2遺伝子増幅の客観的評価と治療層別化
Dual ISH・RNA ISH・IHCを統合し、AIによる信号強度と形態解析. 従来法では見逃されていたHER2 Low/Ultra Low群の可視化を実現.

デジタル病理QCとカラーキャリブレーション
スキャナー間で異なる色調特性を補正し、染色条件や撮影環境の差を数値化・標準化. 解析の再現性を高める.

免疫多重染色と「マスキング」解析技術
単一スライド上で母集団とサブセットを同時解析する独自手法を開発. IgG4関連疾患などにおける定量評価の精度向上.

細胞診標本の3D構築とデジタルPapanicolaou染色
連続切片から立体的に細胞を再構成. デジタル染色で核・細胞質構造を可視化. 細胞診の新しい教育・解析手法を提案.

Objective Evaluation of HER2 Amplification and Therapeutic Stratification
Integration of Dual ISH, RNA ISH, and IHC enables AI-based analysis of signal intensity and cellular morphology, allowing visualization of HER2 Low and Ultra-Low subgroups that were previously overlooked by conventional methods.

Digital Pathology Quality Control and Color Calibration
Development of quantitative frameworks to correct inter-scanner color variation and standardize staining and imaging conditions, enhancing reproducibility and reliability of image-based analysis.

Multiplex Immunostaining and “Masking” Analysis Technique
A novel approach that enables simultaneous quantification of mother and subset cell populations on a single slide, improving accuracy of quantitative assessment in conditions such as IgG4-related disease.

3D Reconstruction and Digital Papanicolaou Staining of Cytology Specimens
Three-dimensional reconstruction of serial cytology sections combined with digital staining techniques allows visualization of nuclear and cytoplasmic architecture, proposing a new framework for cytological education and morphometric analysis.

﻿​Lectures 講演

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conference presentation​s 学会発表

﻿​Writing 執筆

Research Paper 論文

Other Communication Activities 発信

Research 研究

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Digital Pathology Quality Control and Color Calibration Development of quantitative frameworks to correct inter-scanner color variation and standardize staining and imaging conditions, enhancing reproducibility and reliability of image-based analysis.

Multiplex Immunostaining and “Masking” Analysis Technique A novel approach that enables simultaneous quantification of mother and subset cell populations on a single slide, improving accuracy of quantitative assessment in conditions such as IgG4-related disease.